Von Willebrand's disease--diagnostic criteria.
نویسنده
چکیده
منابع مشابه
Diagnostic problems of von Willebrand's disease in a general hospital laboratory.
The expression of variant types of von Willebrand's disease can present an elusive diagnostic problem. Bleeding history of patients can vary greatly, as can the results of tests for the components of the Factor VIII complex. Recent advances in characterizing and measuring the factor VIII complex have greatly improved the diagnosis of the variant forms of von Willebrand's disease. However, some ...
متن کاملType IIB von Willebrand's disease: differential clearance of endogenous versus transfused large multimer von willebrand factor.
The abnormal multimeric composition of plasma von Willebrand factor in type IIB von Willebrand's disease is transiently corrected after infusion of 1-deamino-[8-D-arginine]-vasopressin. However, the larger multimers released into the circulation disappear more rapidly in these patients than in type I von Willebrand's disease or normals. We demonstrate that the larger multimers of normal von Wil...
متن کاملvon Willebrand's disease antigen II. A new plasma and platelet antigen deficient in severe von Willebrand's disease.
Factor VIII-related antigen (VIIIag) is deficient in plasma and platelets of patients with severe von Willebrand's disease. This study reports a second von Willebrand's disease antigen (vWagII), distinct from VIIIag, that is also deficient in the platelets and plasma of patients with severe von Willebrand's disease. VIIIag and vWagII are separable by molecular exclusion chromatography, sucrose ...
متن کاملArteriosclerosis in normal and von Willebrand pigs: long-term prospective study and aortic transplantation study.
In a long-term prospective study, five normal control pigs and five pigs with homozygous von Willebrand's disease received a nonfatty diet from age 3 months to 4 years; then the aortas were analyzed. The fibrous arteriosclerotic plaques in the distal abdominal aortic region involved an average of 28% of the surface area in control pigs and only 7% of the surface area in pigs with von Willebrand...
متن کاملVon Willebrand's disease and pregnancy.
Seven new cases of pregnancy combined with von Willebrand's disease have been reported. Altogether the patients had 11 deliveries, and one abortion after 10 weeks' gestation. The diagnosis was based on the determination of the bleeding time, factor VIII coagulant activity (VIII C), factor VIII-related antigen (VIII RAg) and the ristocetin cofactor (VIII RCoF). Two of our 6 parturients showed pr...
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ورودعنوان ژورنال:
- Blood
دوره 32 4 شماره
صفحات -
تاریخ انتشار 1968